Jade Forest is now carrying ASTAXANTHOL (pronounced asta-zan’-thol) 60 capsules/ bottle. SRP $49, review by Mitch Fleisher M.D., D.Ht., D.A.B.F.M., Dc.A.B.C.T.
ASTAXANTHOL is a uniquely designed, nutriceutical formulation that is an extremely potent, highly bio-available, broad spectrum, anti-inflammatory complex that provides significant, anti-aging protection for the brain, eyes, heart, blood vessels, joints, skin, and all cells, tissues and organs from injury by free radical-induced oxidative stress, esp. that produced by toxic chemicals, and ultraviolet (UV) solar radiation.
The active ingredients, Astaxanthin and Seanol-P, are extremely powerful, carotenoid and bioflavonoid lipophilic antioxidants, respectively, which easily penetrate into all body cells, and serve to both prevent and repair free radical-induced oxidative stress damage to the infrastructure of the brain, heart, and all vital organs, joints, and skin. It will help protect the eyes from UV solar radiation and preserves visual acuity. Gamma-Linoleic Acid (GLA) is an omega-6 essential fatty acid that is very important for helping to control inflammation, and supports healthy skin.
ASTAXANTHOL also represents a new, highly effective form of ‘internal’ sun protection, which reduces the necessity for using messy, topical, sunscreens.
Many commercially available sunscreens contain potentially toxic chemicals, such as retinyl palmitate or retinol, which when exposed to sunlight may exhibit photo-carcinogenic (pro-skin cancer) properties that can damage the skin more than protect it. Topical sunscreens can also inhibit the production of the critically important, anti-cancer nutrient vitamin D3 (cholecalciferol) by preventing the activation by sunshine of the metabolic pathways in the skin. Vitamin D3 is produced by UV solar activation of its precursor 7-dehydrocholesterol, which occurs naturally in the skin of animals.
ASTAXANTHOL does not block sunlight from activating vitamin D3 production. Instead, it prevents and repairs free radical-induced oxidative stress generated by UV solar radiation by protecting the skin from within.
Mechanisms of Action:
Astaxanthin (asta-zan’-thin) is the most potent, lipophilic, carotenoid antioxidant found in nature. It is more powerful than beta-carotene, alpha-tocopherol, lycopene, and lutein, other members of its chemical family. A primary source is the microalgae Haematoccous pluvialis. When its water supply dries up, it must protect itself from ultraviolet radiation. It produces astaxanthin as its survival mechanism, which serves to protect the algae from lack of nutrition, and intense, solar UV radiation.
Astaxanthin is readily soluble in lipids, so it incorporates into all cell membranes.
Astaxanthin exhibits extremely powerful, free radical scavenging activity, and helps to protect all cells, organs and body tissues from oxidative stress damage and inflammation. Astaxanthin is a potent, UVB absorber, and reduces DNA damage.
Astaxanthin is a very potent, natural, anti-inflammatory agent. It has been shown to suppress several, different inflammatory mediators, including tumor necrosis factor alpha (TNF-a), prostaglandin E-2 (PGE-2), interleukin 1B (IL-1b) and nitric oxide (NO).
Astaxanthin is far more effective than other carotenoids at singlet oxygen quenching, a particular type of free radical oxidation. The damaging effects of UV solar radiation, and various organic toxins, are caused by this less-stable form of oxygen. Astaxanthin is 550 times more powerful than vitamin E, and 11 times more powerful than beta-carotene at neutralizing singlet oxygen free radicals.
Astaxanthin crosses the blood-brain barrier and the blood-retinal barrier (whereas, beta carotene and lycopene do not), which brings antioxidant and anti-inflammatory protection to the brain, central nervous system, and eyes, and reducing the risk for Alzheimer’s disease, dementia, cataracts, macular degeneration, and blindness.
Human clinical research studies involving common inflammatory disorders, e.g., carpal tunnel syndrome, tennis elbow (lateral epicondylitis), exercise-related joint soreness, and rheumatoid arthritis, demonstrate the effectiveness of astaxanthin:
- Carpal tunnel syndrome (CTS), a common, repetitive stress injury: CTS is a debilitating condition of the wrist that manifests as numbness, pain, and sometimes paralysis of the hand and fingers. A study by the Health Research and Studies Center found eight weeks of astaxanthin supplementation resulted in significant pain reduction, both in terms of severity and duration, leading researchers to conclude that astaxanthin might be a viable alternative to surgery.
- Tennis elbow (lateral epicondylitis): caused by inflamed tendons, tennis elbow results in pain and decreased grip strength when gripping something with your hand. Another study by the Health Research and Studies Center involved giving patients with tennis elbow an eight-week course of astaxanthin. The treatment group showed a 93 percent improvement in grip strength, as well as decreased pain.
- Post-exercise joint soreness: In 2001, Dr. Andrew Fry of the University of Memphis studied the effects of astaxanthin on healthy individuals who trained with weights, who would typically experience exercise-induced joint soreness. Dr. Fry gave young male subjects astaxanthin for three weeks, during which time they performed strenuous workouts, and then re-evaluated them for knee pain. The placebo group experienced post-training knee soreness, lasting up to 48 hours after their workouts. However, the treatment group who received astaxanthin exhibited no increase whatsoever in knee joint soreness following workouts. [Fry, A. (2001) “Astaxanthin Clinical Trial for Delayed Onset Muscular Soreness.” Human Performance Laboratories, The University of Memphis, Report 1, August 16, 2001.]
- Rheumatoid arthritis: After receiving astaxanthin supplementation for eight weeks, RA patients showed a 35 percent improvement in pain levels, as well as a 40 percent improvement in their ability to perform range of motion, and daily activities [Journal of the American College of Nutrition. 21(5):Oct, 2002.]
A recent study of astaxanthin’s neuro-protective capacity was done at Nagoya University in Japan. Human brain cells were subjected to an oxidative stress-induced neuronal cell damage system. Significant protection was demonstrated in cells pre-treated with astaxanthin. In addition, pre-treatment with astaxanthin inhibited the generation of reactive oxygen species. The authors concluded, “The neuroprotective effect of astaxanthin is suggested to be dependent upon its antioxidant potential and mitochondria protection; ergo, it is strongly suggested that treatment with astaxanthin may be effective for oxidative stress-associated neuro-degeneration, and a potential candidate for natural brain food.”
Astaxanthin has also been demonstrated to contribute to cancer chemoprevention, and antitumor activity in animals and humans, as well as to improve male fertility, and preserve the cosmetic properties of the skin via protection from sun damage.
The most recent study of astaxanthin’s neuro-protective capacity was published in the British Journal of Nutrition, which assessed the efficacy of astaxanthin supplementation in the prevention of dementia. The 12-week study included a total of thirty middle-aged and senior participants who were assigned to receive either 6 or 12 mg astaxanthin or placebo daily. The results revealed that after 12 weeks, those who consumed astaxanthin had markedly lower levels of PLOOH (free radical compounds that accumulate abnormally in the red blood cells and are thought to contribute to dementia). Levels of PLOOH were 40 and 50 percent lower, in the 6 and 12 mg groups, respectively, compared with no significant change in the placebo group. Based upon these findings, the researchers concluded that astaxanthin reduces levels PLOOH, which may lower the risk of dementia.
Another recent study examined the effect of astaxanthin supplementation in overweight and obese adults. The study included 23 adults with BMI of greater than 25 who were randomly assigned to receive either 5 mg or 20 mg of astaxanthin daily for three weeks. Oxidative stress biomarkers were measured at baseline and then again 1, 2 and 3 weeks after astaxanthin supplementation. At the end of the study, it was found that both groups saw marked increases in levels of the body’s own antioxidant defenses, as well as significant decreases in biomarkers of oxidative stress. Although plasma concentrations of astaxanthin were higher in the group receiving 20 mg per day, there were no significant differences in levels of biomarkers between the two groups. These findings suggest that 5 mg of astaxanthin may provide beneficial protection against oxidative stress in overweight and obese adults.
Seanol-P (SeaPolynol, Ecklonia cava extract) is the most powerful and long-acting, natural antioxidant now known. Unlike virtually all of the land-based, ‘hydrophilic’ (water-soluble) polyphenols, including catechins and EGCG from green tea extract, anthocyanosides from bilberry and blueberry extracts, proanthocyanidins from grape seed and pine bark extracts, etc., the effectiveness of Seanol-P is, in part, due to the fact that these sea-based, polyphenol-phlorotannin extracts contain large amounts of ‘lipophilic’ (fat-soluble), ‘hydrophobic’ (water-insoluble) compounds. This gives Seanol-P the unique ability to be easily absorbed into and concentrated in all the cells of the body, and also pass through the blood-brain barrier, thereby helping to protect and improve brain function, memory and mental clarity. In addition, the ‘lipophilic’ (fat-soluble) properties of the special polyphenols in Seanol-P allow it to remain in the body of humans and other mammals up to 12 hours, in contrast to the very short, thirty-minute half-life of the ‘hydrophilic’ (water-soluble), land-based polyphenol sources. The ORAC score for antioxidation potential (8,300) of Seanol-P is significantly higher than most known land-based polyphenols. Phlorotannins are known to be potent antioxidants and anti-inflammatory agents that help to prevent and alleviate inflammatory and degenerative disorders of the central nervous system (CNS) and the entire body.
Seanol-P is rich in lipophilic polyphenol/phlorotannin complexes possessing long lasting, extremely potent, anti-oxidant, anti-inflammatory properties and is the result of over 14 years and more than $35 million of focused developmental funding and research.
In addition, the lipophilic polyphenol/phlorotannin complexes in Seanol-P have a very long half-life, remaining in the mammalian metabolism up to 12 hours, as opposed to the brief, 30 minute half-life of the hydrophilic, land-based polyphenols. The ORAC score of Seanol-P for anti-oxidation potential of 8,300 units are significantly higher than those of most known hydrophilic, land-based polyphenols.
Depending upon the medical application examined, the in-vivo potency of Seanol-P tends to be from 100 to 1,000 times more than a similar quantity of land-based polyphenols, resulting both from its higher anti-oxidant potential, as well as its 24 times greater metabolic half-life.
As a result of over 14 years of in-vitro, in-vivo basic science and human clinical research, Seanol-P has been proven to provide the following cardiovascular metabolic benefits:
- Uniquely strong anti-oxidant scavenging of lipids, calcium and cholesterol, as well as ‘free radicals’ from the cardiovascular system, thereby lowering risk of cardiovascular events and stroke, lowering cholesterol levels and reducing vasculitis-induced neuropathy.
- Strong anti-plasmin inhibition effect, i.e., normalizes vascular blood flow, thereby lowering blood pressure and increasing arterial blood flow.
- Strong elastase agonist effect, thereby increasing the flexibility of the vascular system and helping normalize blood flow and blood pressure.
- Significant anti-inflammatory effect, by inhibition of the Nf-kB inflammatory pathway, which also serves to normalize blood glucose levels and lead to statistically significant re-establishment of insulin sensitivity in the pancreas.
A clinical study of Seanol-P was conducted confirming its capacity to regenerate vascular endothelium and plasticity of blood vessels after 6 weeks of treatment by measuring FMD (Flow-mediated Dilation) and NMD (Nitroglycerin-mediated Dilation) of both normal and CAD (with narrowed coronary artery by 50+%) groups. FMD indicates the NO (Nitric oxide) releasing capacity of endothelial cells to expand blood vessel by detecting shear stress caused by incoming blood flow. In other words, someone with damaged vascular endothelium shows a low FMD value compared with a healthy individual. After 6 weeks of treatment with Seanol-P, clinical data showed that FMD, the endothelium-dependent dilation, was greatly enhanced in the CAD (coronary artery disease) group, indicating its remarkable activity in inducing recovery of endothelial cells. NMD, the endothelium-independent dilation, which represents vascular elasticity, also showed remarkable improvement in the CAD group, again corroborating the ability of Seanol-P to help support the restoration of vascular integrity by both preventing and reversing atherosclerosis.
In another study, subjects were advised to ingest 6 capsules daily (3 capsules 2 hours before lunch, 3 capsules 2 hours after dinner) for eight weeks. Each capsule contained 100mg of Seanol-P. As noted in the table below, Seanol-P improved all of the cholesterol parameters, along with reducing triglyceride levels.
Gamma-Linolenic Acid (GLA) is an omega-6 fatty acid that is found mostly in plant-based oils, and is esp. concentrated in borage seed oil.
From GLA, the body forms dihomo-γ-linolenic acid (DGLA), an anti-inflammatory omega fatty acid. DGLA is the precursor of the prostaglandin PGH1, which in turn forms PGE1 and the thromboxane TXA1. PGE1 has a role in regulation of immune system function. TXA1 modulates the pro-inflammatory properties of the thromboxane TXA2, thereby serving to help control systemic inflammation.
GLA has been demonstrated to reduce inflammation in the joint and skin tissues, to significantly reduce pain in rheumatoid arthritis, to help control dermatitis, and preserve the moisture and smooth texture of the skin.
- Help protect the brain, eyes, heart, blood vessels, joints, skin, and all cells, tissues and organs from injury by free radical-induced oxidative stress
- Help protect the eyes from UV solar radiation, and preserve visual acuity
- Help control common inflammatory disorders, e.g., carpal tunnel syndrome, tennis elbow (lateral epicondylitis), exercise-related joint soreness, and rheumatoid arthritis
- Help contribute to cancer chemoprevention, and antitumor activity
- Help improve male fertility via enhancing healthy sperm function
- Helps reduce free radicals in red blood cells & thereby may help prevent dementia
- Help optimize blood lipid (cholesterol and triglyceride) levels by decreasing VLDL and LDL cholesterol, as well as Lipoprotein A, and concomitantly increasing protective HDL cholesterol
- Help improve cardiovascular function via vasodilatation, hypotensive (blood pressure lowering) effects and enhancement of peripheral blood circulation
- Help protect against arteriosclerosis and atherosclerosis (hardening of the arteries), cardiovascular disease, cerebrovascular disease (stroke) and hypertension
- Help preserve the cosmetic integrity of the skin via protection from toxic chemicals, sun damage, and inflammation
- One to two chlorophyll vegi-capsules daily, before or with meals.
When used as an ‘internal’ oral sunscreen to help prevent sunburns, take two to four vegi-capsules daily, depending on the duration and intensity of sun exposure, and the fairness of the skin; the fairer the skin, the more that is necessary.
The components of ASTAXANTHOL, including Astaxanthin, Seanol-P and Gamma-Linoleic Acid, are considered safe when used as directed in the above-recommended dosage ranges.